Antimicrobial susceptibility and molecular characterization of macrolide resistance of
Mycoplasma bovis isolates from multiple provinces in China |
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| Authors: | Ling-Cong KONG Duo GAO Bo-Yan JIA Zi WANG Yun-Hang GAO Zhi-Hua PEI Shu-Ming LIU Jiu-Qing XIN Hong-Xia MA |
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| Affiliation: | 1)College of Animal Science and Technology, Jilin Agricultural University, Xincheng Street No.#2888, Changchun 130118, P.R. China;2)National Contagious Bovine Pleuropneumonia Reference Laboratory, Division of Bacterial Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin 150000, P.R. China |
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| Abstract: | ![]()
Mycoplasma bovis has spread widely throughout the world via animal movement and has becomean important pathogen of bovine respiratory disease. However, the minimum inhibitory concentrations ofantimicrobials for Mycoplasma bovis have not been studied in China. The objective of thisstudy was to determine the prevalence and antibiotic resistance of Mycoplasma bovis isolatedfrom young cattle with respiratory infection in China. Mycoplasma bovis was detected in 32/45bovine respiratory infection outbreaks at beef farms in 8 provinces in China. The isolates were susceptible orhad medium sensitivity to ciprofloxacin, enrofloxacin and doxycycline, but were frequently resistant tomacrolides (13/32, 41%). An A2058G (Escherichia coli Numbering) mutation located in therrnA operon in domain V of 23S rRNA was observed in strains that were resistant tomacrolides. This single mutations at the rrnA operon in domain V of 23S rRNA may play an important role in theresistance of Mycoplasma bovis strains to macrolides. |
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| Keywords: | antimicrobial susceptibility bovine respiratory infection macrolides mycoplasma bovis target mutation |
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