Thymol attenuates allergic airway inflammation in ovalbumin (OVA)-induced mouse asthma |
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| Institution: | 1. College of Veterinary Medicine, Jilin University, 5333#, Xian Road, Changchun 130062, PR China;2. Norman Bethune College of Medicine, Jilin University, Xinming Road, Changchun 130021, PR China;1. College of Animal Science and Technology, Guangxi University, Nanning, Guangxi 530005, PR China;2. Guangxi Engineering Research Center for Veterinary Medicine, Nanning, Guangxi 530007, PR China;3. College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin 130062, PR China;1. The Second Department of Paediatrics, the First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, People''s Republic of China;2. Department of Pharmacy, the First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, People''s Republic of China;3. The First Department of Paediatrics, the First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, People''s Republic of China;4. Department of Endemic Disease, the Second Affiliated Hospital of Harbin Medical University, Harbin 150001, People''s Republic of China;1. Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju-si, Chungcheongbuk-do 28116, Republic of Korea;2. College of Pharmacy, Chungbuk National University, Cheongju-si, Chungcheongbuk-do 28160, Republic of Korea;3. College of Pharmacy, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 305-764, Republic of Korea;4. Laboratory Animal Resources Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong Health Technology Administration Complex, Cheongju, Chungcheongbuk 28159, Republic of Korea;1. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;2. Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;3. Air Pollution Research Center, Iran University of Medical Sciences, Tehran, Iran;4. Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran;5. Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran |
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| Abstract: | Thymol, a naturally occurring monocyclic phenolic compound derived from Thymus vulgaris (Lamiaceae), has been reported to exhibit anti-inflammatory property in vivo and vitro. However, the mechanism of thymol is not clear. The aim of the present study was to investigate the effects of thymol on allergic inflammation in OVA-induced mice asthma and explore its mechanism. The model of mouse asthma was established by the induction of OVA. Thymol was orally administered at a dose of 4, 8, and 16 mg/kg body weight 1 h before OVA challenge. At 24 h after the last challenge, mice were sacrificed, and the data were collected by various experimental methods. The results revealed that pretreatment with thymol reduced the level of OVA-specific IgE, inhibited recruitment of inflammatory cells into airway, and decreased the levels of IL-4, IL-5, and IL-13 in BALF. Moreover, the pathologic changes of lung tissues were obviously ameliorated and goblet cell hyperplasia was effectively inhibited by the pretreatment of thymol. In addition, thymol reduced the development of airway hyperresponsiveness and blocked the activation of NF-κB pathway. All data suggested that thymol ameliorated airway inflammation in OVA-induced mouse asthma, possibly through inhibiting NF-κB activation. These findings indicated that thymol may be used as an alternative agent for treating allergic asthma. |
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