转基因植物疫苗的最新研究进展

随着分子生物学技术与重组DNA技术的不断发展、基因工程疫苗研究的不断深入,传统疫苗体现出诸多缺陷。因此,利用植物基因工程方法开发新疫苗逐渐成为疫苗研究的重点。目前,在转基因植物中表达的主要有大肠杆菌热敏肠毒素B亚单位、乙型肝炎病毒表面抗原、诺沃克病毒外壳蛋白、口蹄疫病毒、狂犬病病毒糖蛋白、变异链球菌表面蛋白和艾滋病病毒抗原等10多种疫苗。与传统疫苗相比,转基因植物疫苗具有价廉、安全、有效、易于运输与保存等优点,因而成为现代疫苗学研究的一个热点。文章综述了国内外植物基因工程疫苗的现状及最新研究进展,对其存在的问题及对策进行讨论,对其发展前景进行展望。

The Latest Research Progress on Transgenic Plant Vaccines

Along with the development of molecular biology technology and the recombinant DNA technology, and with the deepening research of genetic engineering vaccine, traditional vaccine has already reflected many defects, using the technology of plant genetic engineering to develop new vaccine has become the focus of vaccine research gradually. This paper introduced the definition of transgenic plant vaccine firstly, and summarized its advantages. Compared with traditional vaccine, the transgenic plant vaccine was cheaper, safer, more efficient, easier to be transported and stored. Therefore, transgenic plant vaccine was becoming a hot issue in vaccinology. At present, the number of transgenic plant vaccine found in foreign countries more than 10 kinds. Also the paper reviewed transgenic plant vaccine’s present situation and mainly introduced the latest research progress, including its immune protection effect. Some issues and countermeasures were discussed with regard to the further development of plant-based on vaccine, as well as prospect of studies on plant-based vaccine were also introduced.