小RNA病毒基因组3'非编码区.结构与功能研究进展

小RNA病毒属于单股正链RNA病毒,包括肠道病毒属、鼻病毒属、心脏病毒属、口疮病毒属和肝病毒属等几个主要的属.口蹄疫病毒(FMDV)、脊髓灰质炎病毒(PV)、丙型肝炎病毒(HCV)、脑心肌炎病毒(EMCV)是该科病毒的典型代表.小RNA基因组的末端具有非编码区(UTR),是病毒基因组复制的主要调控位点,3'非编码(3'...

Progress on Structure and Function of Picornavirus 3′Untranslated Region

Picornaviruses are single plus strand viruses,mainly including Enterovirus,Rhinovirus,Cardiovirus,Aphthovirus and Hepatovirus.Foot-and-mouth disease virus(FMDV),poliovirus(PV),Hepatitis C virus(HCV),encephalomyocarditis(EMCV) are typical in this family.Untranslated region(UTR) wich regulates replication situated in the termination of picornavirus genome.3′UTR is the first combining site of replicative enzyme,second-level structure of it plays an important role in the process of virus translation and replication.3′UTR which can be identified and combined by replicative enzyme mainly participate synthesis of minus strand.3′UTR educe basilica action in the process of translation and the formation of infectivity virion.Hence,researching the 3′UTR of picornavirus possess crucial significance.It decides the specific locations and key features of replication and expression in 3′UTR and establishes infarctate rationale for the research of other plus strand picornavirus genome replication.