| 非酒精性脂肪肝病的研究进展 |
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| 引用本文： | 卢薇, 邵宛芳, 卢凤美, 等. 德昂族酸茶防治非酒精性脂肪肝作用的研究[J]. 云南农业大学学报（自然科学）, 2020, 35(1): 114-121. DOI: 10.12101/j.issn.1004-390X(n).201909029 |
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| 作者姓名： | 卢薇 邵宛芳 卢凤美 谢桂华 钟凯 熊江波 吴吉 侯艳 |
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| 作者单位： | 1.云南省文山州经济作物工作站，云南 文山 663099;2.云南农业大学 龙润普洱茶学院，云南 昆明 650201;3.滇西应用技术大学 普洱茶学院，云南 普洱 665000;4.云南德宏芒市德凤茶业有限公司，云南 德宏 678400 |
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| 基金项目： | 国家现代农业茶叶产业体系专项资金（CARS-23）；云南德凤茶业有限公司合作项目（KX141721） |
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| 摘 要： | ttttt目的ttttt酸茶为德昂族独特的茶叶制品。探究酸茶对防治外源性膳食诱导引起的非酒精性脂肪肝的预防作用。ttttttttttttt方法ttttt通过动物试验，以保肝药为对照，分别灌胃不同剂量的酸茶水浸提物，为期4周。对血脂指标、肝功能指标、抗氧化指标以及胰岛素样生长因子-1 (IGF-1)和细胞色素P4502E1 (CYP2E1)的表达量进行检测，对试验大鼠肝脏组织进行病理性观察及评价。tttttttttttttttttt结果ttttt酸茶能够有效降低非酒精性脂肪肝试验大鼠血清中CHOL和TG的含量，同时增加HDL-C的水平；可降低大鼠血清中AST和ALT活性；升高大鼠血清和肝脏组织GSH-Px和SOD的活性。高剂量酸茶能够改善由于脂质堆积引起的肝组织病变问题。酸茶可提高试验大鼠肝脏组织中IGF-1 mRNA的表达，抑制CYP2E1 mRNA的表达。tttttttttttttttttt结论ttttt德昂族酸茶具有预防大鼠非酒精性脂肪肝的作用。tttt
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| 关 键 词： | 德昂族 酸茶 非酒精性脂肪肝 预防作用 |
| 收稿时间： | 2019-09-24 |
| 修稿时间： | 2019-12-08 |
Review article: drug therapy for non-alcoholic fatty liver disease |
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| Wei LU, Wanfang SHAO, Fengmei LU, et al. The Preventive Effect of Suancha from De’ang Nationality on Non-alcoholic Fatty Liver[J]. JOURNAL OF YUNNAN AGRICULTURAL UNIVERSITY（Natural Science）, 2020, 35(1): 114-121. DOI: 10.12101/j.issn.1004-390X(n).201909029 |
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| Authors: | Wei LU Wanfang SHAO Fengmei LU Guihua XIE Kai ZHONG Jiangbo XIONG Ji WU Yan HOU |
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| Affiliation: | 1.Wenshan Economic Crops Station of Yunnan, Wenshan 663099, China;2.College of Longrun Pu-erh Tea, Yunnan Agricultural University, Kunming 650201, China;3.West Yunnan University of Applied Sciences College of Tea (Pu’er), Pu’er 665000, China;4.Yunnan Dehong Mangshi Defeng Tea Company Limited, Dehong 678400, China |
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| Abstract: | tttttPurposetttttSuancha was the unique tea product from De’ang Nationality. Our aim was to study the effect of Suancha on the non-alcoholic fatty liver caused by exogenous dietary induction.tttttttttttttMethodtttttContrast with hepatoprotectants, the rats were given different does for 4 weeks, and then executed. The peripheral blood, blood lipid index, liver function index and antioxidant index were detected; the expression insulin growth factor (IGF-1) and cytochrome P4502E1 (CYP2E1) were studied; pathological observation and evaluation on liver tissue of rats were carried out.ttttttttttttttttttResulttttttSuancha could effectively reduce the content of CHOL and TG in the serum of rats with non-alcoholic fatty liver, and increase the level of HDL-C; it could reduce the activity of AST and ALT in rat serum; it could increase enzyme activity level of GSH-Px and SOD in rat’s serum and liver; high-dose Suancha could improve liver tissue damage caused by lipid accumulation; Suancha could increase the expression of IGF-1 mRNA in liver tissue of test rats and inhibit the expression of CYP2E1 mRNA.ttttttttttttttttttConclusiontttttSuancha from De’ang Nationality has a positive effect on non-alcoholic fatty liver on rats.tttt |
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| Keywords: | De’ang Nationality Suancha non-alcoholic fatty liver prevention |
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