| 含吡唑-4-甲酰胺的嗜球果伞素类化合物的设计、合成及杀虫活性 |
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| 引用本文： | 楼佳明,郝树林,方佳琪,杜晓华.含吡唑-4-甲酰胺的嗜球果伞素类化合物的设计、合成及杀虫活性[J].农药学学报,2021,23(6):1108-1116. |
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| 作者姓名： | 楼佳明 郝树林 方佳琪 杜晓华 |
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| 作者单位： | 1.浙江工业大学 催化加氢中心，浙江省绿色农药清洁生产技术研究重点实验室，浙江省绿色农药协同创新中心，杭州 310014 |
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| 基金项目： | 国家重点研发计划(2016YFD0300708). |
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| 摘 要： | 为了发现新的农用高活性化合物，将具有杀螨活性的嗜球果伞素类化合物与具有杀菌活性的吡唑酰胺类化合物的活性亚结构进行拼接，设计并合成了16个新化合物，通过核磁共振氢谱、碳谱及高分辨质谱等手段表征了其结构。生物活性测试结果表明，目标化合物虽然没有预期的杀螨和杀菌活性，但是表现出了良好的杀虫活性，其中8个化合物在500 mg/L下对黏虫Mythimna separata的杀虫活性为100%。
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| 关 键 词： | 嗜球果伞素 吡唑-4-甲酰胺 嘧啶硫醚 黏虫 杀虫活性 |
| 收稿时间： | 2021-04-30 |
Design,synthesis and insecticidal activity of strobilurin compounds containing pyrazole-4-carboxamide |
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| Institution: | 1.Catalytic Hydrogenation Research Center, Zhejiang University of Technology, Zhejiang Key Laboratory of Green Pesticides and Cleaner Production Technology, Zhejiang Green Pesticide Collaborative Innovation Center, Hangzhou 310014, China |
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| Abstract: | To discovery novel pesticidal compounds, 16 new compounds were designed and synthesized by combining several active sub-structures of miticidal strobilurins and fungicidal pyrazole carboxamides. Their structures were determined by 1H NMR, 13C NMR and HRMS. The biological activity assay results showed that all target compounds had poor miticidal and fungicidal activities, however, some target compounds had good insecticidal activities. The mortalities against Mythimna separata of 8 compounds were 100% at 500 mg/L. |
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