| 大黄素新型制剂抗肿瘤作用研究进展 |
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| 引用本文： | 马明星,黄嬛,李明娟,蒋小红. 大黄素新型制剂抗肿瘤作用研究进展[J]. 安徽农业科学, 2016, 0(27): 144-146. DOI: 10.3969/j.issn.0517-6611.2016.27.049 |
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| 作者姓名： | 马明星 黄嬛 李明娟 蒋小红 |
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| 作者单位： | 1. 嘉兴学院医学院，浙江嘉兴314001; 华东理工大学药学院，上海200237;2. 嘉兴学院医学院,浙江嘉兴,314001 |
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| 基金项目： | 嘉兴市科技计划项目(2014AY21037)。 |
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| 摘 要： | 通过检索近几年中外相关研究文献,概述了大黄素固体脂质纳米粒、包合物、聚合物胶束、脂质体、纳米乳等新型载药系统的制备工艺、工艺优化和包封率情况;同时进一步介绍了大黄素新型制剂在发挥抗肿瘤药效时具有的组织相容性好、治疗浓度低、靶向性好、药物溶解度高、半衰期久等显著优势,为大黄素新型制剂抗肿瘤的进一步研究提供试验依据和理论参考。
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| 关 键 词： | 大黄素 新剂型 抗肿瘤 |
Research Progress of Anti-tumor Effects of Emodin New Preparation |
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| MA Ming-xing,HUANG Xuan,LI Ming-juan,JIANG Xiao-hong. Research Progress of Anti-tumor Effects of Emodin New Preparation[J]. Journal of Anhui Agricultural Sciences, 2016, 0(27): 144-146. DOI: 10.3969/j.issn.0517-6611.2016.27.049 |
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| Authors: | MA Ming-xing HUANG Xuan LI Ming-juan JIANG Xiao-hong |
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| Abstract: | By retrieving relevant literatures both at home and abroad in recent years, we summarized the preparation process, process optimi-zation and encapsulation of emodin new delivery system, including solid lipid nanoparticles, clathrate compounds, polymeric micelles, lipo-somes, nanoemulsion and so on.Meanwhile, several significant advantages of emodin new formulations when playing an anti-tumor role were further introduced, which had the advantages of good bio-compatibility, low treatment concentration, good target specific selectivity, high solu-bility and long half-life.This research provided experimental evidence and theoretical reference for the further study of anti-tumor of emodin novel preparation. |
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| Keywords: | Emodin New preparation Anti-tumor |
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