| 植物DNA双链断裂损伤修复机制研究进展 |
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| 引用本文： | 朱彩霞,古佳玉,邵群,王晶,刘录祥.植物DNA双链断裂损伤修复机制研究进展[J].中国农业科技导报,2010,12(5):17-23. |
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| 作者姓名： | 朱彩霞 古佳玉 邵群 王晶 刘录祥 |
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| 作者单位： | (1.中国农业科学院作物科学研究所,国家农作物基因资源与基因改良重大科学工程, 北京 100081,2.山东师范大学生命科学学院, 济南 250014) |
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| 基金项目： | 国家863计划项目，"十一五"国家科技支撑计划项目，农业部农业公益性行业科研专项，国际原子能机构项目 |
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| 摘 要： | DNA双链断裂(DSBs)是细胞最严重的损伤形式之一。高等动植物中主要通过非同源末端连接（NHEJ）途径进行DNA双链断裂修复。该途径不依赖DNA同源性,由一些修复因子如：Ku蛋白异二聚体、DNA-PKcs 、XRCC4、ligaseⅣ等,将断裂末端直接连接进行修复。综述了植物DNA双链断裂损伤修复的主要途径及其相关基因研究的进展,探讨了植物DNA损伤修复研究中存在的问题与发展方向。
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| 关 键 词： | DNA双链断裂 损伤修复 非同源末端连接 Ku蛋白 XRCC4 |
| 收稿时间： | 2010-03-08 |
| 修稿时间： | 2010-04-17 |
Advances in Repair Mechanism of |DNA Double-strand Break Damage in Plant |
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| ZHU Cai-xia,GU Jia-yu,SHAO Qun,WANG Jing,LIU Lu-xiang.Advances in Repair Mechanism of |DNA Double-strand Break Damage in Plant[J].Journal of Agricultural Science and Technology,2010,12(5):17-23. |
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| Authors: | ZHU Cai-xia GU Jia-yu SHAO Qun WANG Jing LIU Lu-xiang |
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| Institution: | (1.National Key Facility for Crop Gene Resources and Genetic Improvement|Institute of Crop Sciences, Chinese Academy of |Agricultural Sciences, Beijing 100081|2.College of Life Science, Shandong Normal University, Jinan 250014, China) |
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| Abstract: | The DNA double-strand breaks (DSBs) is one of the most serious form of DNA damage. Non-homologous end-joining (NHEJ) is the major pathway to repair DNA double-strand break damages in both higher plants and animals. The NHEJ pathway does not rely on DNA homology, while the number of such repair factors as Ku protein heterodimer, DNA-PKcs, XRCC4 and ligaseⅣ, will be directly joined the end to repair. The research progresses in major repair pathway and key genes involving in DNA double-strand break damages in plant are summarized. The existing problems and perspectives in this field are also discussed. |
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| Keywords: | XRCC4 |
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