茶枝柑皮提取物血清药物化学的初步研究

目的]对茶枝柑皮提取物进行血清药物化学研究。方法]采用HPLC方法测定分析茶枝柑皮提取物给药后的含药血清,鉴定茶枝柑皮提取物灌胃后大鼠血中移行成分。结果]在茶枝柑皮提取物含药血清中发现了17个入血成分,其中5个为原型成分,其余几个可能为代谢产物。结论]入血原型成分主要为多甲氧基黄酮川陈皮素和桔皮素等成分,深入研究其血清药物化学的表征,将有助于探索茶枝柑皮提取物的功效物质基础,探明其中的功能因子。

Pilot Study on Serum Pharmacochemistry of Extract of Citrus reticulata 'Chachi' Peel

Objective] To study the serum pharmacochemistry of extract from Citrus reticulata ’Chachi’ Peel.Method] Based on the establishment of HPLC fingerprints of extract of C.reticulata peel,the constituents absorbed into blood were determined by comparing HPLC fingerprints of the methanol extract of C.reticulata peel,medicated plasma with extract of C.reticulata peel and blank serum.Result] Seventeen compounds absorbed into blood were found in medicated serum,among which five were original constituents of extract from C.reticulata peel and the other might be metabolites of the original constituents.Conclusion] Polymethoxylated flavones,nobiletin and hesperetin which are absorbed into blood might be bioactive components of extract of C.reticulata peel.Further studies on them will help clarify the bioactive constituents and functional food factors of extract from C.reticulata peel.