马来酸酐合成富马酸二甲酯新工艺及应用

提出了一种合成富马酸二甲酯的新方法。以马来酸酐为原料 ,对甲苯磺酸作催化剂 ,二氯甲烷作溶剂与甲醇作用进行酯化反应 ,所得产物再在氯存在下经光照可异构成富马酸二甲酯。研究了溶剂种类、甲醇用量、反应时间对DMF产率的影响 ,确定了最佳工艺条件 :马来酸酐 9 8g、甲醇 35ml、二氯甲烷 2 5ml、对甲苯磺酸 0 2 5g ,在10 6℃搅拌回流反应 3小时。在此条件下DMF产率可达 90 % ,并得到了一些物性和毒性数据 ,简述了其应用领域

New Synthesis Way And Application of Dimethyl Fumaric From Maleic Anhydride

A new method of synthesis of dimethl fumarate was put forward.Maleic anhydride is used as the raw material,esterification reaction takes place between maleic anhydride and methanol using P-toluene sulfonic acid as catalyst and methane dichloride as solvent.Then the intermediate dimethyl maleate is isomerized into dimethyl fumarate under the condition of light and chlorine. After the study of solvent kinds, amount of methanol use, span of reaction, the best industrial method comes to be established as follows: 9 8g Maleic anhydride,35ml methanol,25ml methane dichloride,0 25g P-toluene sulfonic acid,3-hour reaction agatated and refluxed at 106℃ .As a result of the above condition, DMF yield is up to 90%.And the statistics of some features of physics and toxicity is gained, introducing briefly its field of application.