牛结节性皮肤病病毒研究进展

牛结节性皮肤病(LSD)在全世界范围内均有流行和记载，对我国养牛业构成了严重的威胁。接种疫苗是目前防控LSDV最有效的方法，其中减毒活疫苗在许多国家均有使用。近年研究表明，LSDV活疫苗的使用会造成疫苗重组病毒的流行，接种后会引起动物不同程度的不良反应。对LSDV的病原学特征、分离鉴定方法、流行病学的情况、检测方法以及LSDV疫苗的研究进展进行了阐述，以期为牛结节性皮肤病的免疫预防以及鉴别诊断提供研究思路。

Research Progress on lump skin disease virus

Lump skin disease (LSD) has been reported worldwide and in many parts of the country, posing a serious threat to China''s cattle industry. Vaccination is the most effective way to control LSDV and live attenuated vaccines are currently used in many countries. Recent studies have shown that the use of live LSDV vaccines can cause epidemics of vaccine recombinant viruses and can cause varying degrees of adverse reactions in animals after vaccination. In this paper, the pathogenic characteristics, isolation and identification methods, epidemiology of LSDV, detection methods and research progress of LSDV vaccine were described in order to provide research ideas for immunoprophylaxis and differential diagnosis of lump skin disease.