Analgesic and antidiarrheal properties of Ocimum selloi essential oil in mice |
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Authors: | Franca Carolina S Menezes Fábia S Costa Larissa C B Niculau Edenilson S Alves Péricles B Pinto José E B Marçal Rosilene M |
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Institution: | Physiology Department (DFS), Federal University of Sergipe, S?o Cristov?o, Sergipe, CEP 49.100-000, Brazil. carolinafranca18@yahoo.com.br |
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Abstract: | Ocimum selloi essential oil (2, 20, and 200 mg/kg; p.o.) reduced, in a dose-dependent way, the abdominal contraction induced by acetic acid (0.6%; i.p.) and the diarrhea episodes induced by castor oil in mice. At the higher dose (200 mg/kg; p.o.), the essential oil significantly reduced intestinal transit (P<0.05) in the charcoal meal test. The main component detected in O. selloi essential oil was methyl chavicol (98%; GC and GC/MS).These effects seems to support the use of O. selloi against diarrhea, intestinal spasm and visceral pain. |
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