Experimental Salmonellosis in Guinea-pigs: Haematological and Biochemical Studies |
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Authors: | Gupta R.P. Verma P.C. Chaturvedi G.C. |
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Affiliation: | (1) Department of Veterinary Pathology, CCS Haryana Agricultural University, Hisar, 125 004, India;(2) Department of Veterinary Microbiology, CCS Haryana Agricultural University, Hisar, 125 004, India |
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Abstract: | Some haematological and biochemical parameters were studied in guinea-pigs infected intraperitoneally with Salmonella dublin 493 at 1×106 viable cells per animal. The infected animals showed a rise in temperature within 24 h, followed by depression and loss of body weight. On the 15th day post infection, haematological studies revealed a significant increase in the total leukocyte count due to both lymphocytosis and neutrophilia, and a decrease in the total erythrocyte count and haemoglobin concentration. There was also a significantly higher mean corpuscular volume and lower mean corpuscular haemoglobin concentration, indicating a macrocytic hypochromic anaemia. The infection caused a significant increase in alanine aminotransferase activity and creatinine, blood urea nitrogen and globulin concentrations, and a decrease in albumin and triiodothyronine. There was no significant effect on serum total protein or on thyroxine, or in the activity of aspartate aminotransferase in the serum. |
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Keywords: | guinea-pig haematology pathogenesis Salmonella dublin serum biochemistry |
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