| 猪口服免疫F18ac~+非产肠毒素大肠杆菌疫苗候选株后小肠免疫细胞的组织形态学特征 |
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| 引用本文： | 董立伟,张江英.猪口服免疫F18ac~+非产肠毒素大肠杆菌疫苗候选株后小肠免疫细胞的组织形态学特征[J].四川畜牧兽医,2012,39(11):22-24,27. |
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| 作者姓名： | 董立伟 张江英 |
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| 作者单位： | 扬州大学兽医学院,江苏扬州,225009 |
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| 摘 要： | 由F4+和(或)F18+产肠毒素大肠杆菌(ETEC)引起的腹泻和肠毒血症是乳猪及断奶仔猪的多发病。本文通过对断奶仔猪小肠淋巴样细胞亚群表型进行定量分析,检测和评估了F18ac+非ETEC弱毒疫苗候选株对F4ac+ETEC感染的免疫原性及保护效力;同时还评估了左旋咪唑作为一种免疫应答调节剂(IRM)的调节效能及其与试验疫苗联用的佐剂活性。
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| 关 键 词： | 非特异性/特异性免疫 大肠杆菌 肠道免疫细胞 断奶仔猪 |
Histomorphometric characteristics of immune cells in small intestine of pigs perorally immunized with vaccine candidate F18ac＋ nonenterotoxigenic E.coli strain |
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| Institution: | DONG Li-wen, ZHANG Jiang-ying (Veterinary College of Yangzhou University,Jiangsu Yangzhou 225009,China) |
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| Abstract: | Colidiarrhea and colienterotoxemia caused by F4＋ and/or F18＋ enterotoxigenic F. coli （ETEC） strains are the most prevalent infections of suckling and weaned pigs. Here we tested the immunogenicity and protective effectiveness of attenuated F18ac＋ non-ETEC vaccine candidate strain against challenge infection with F4a＋ ETEC strain by quantitative phenotypic analysis of small intestinal leukocyte subsets in weaned pigs. We also evaluated levamisole as an immune response modifier （IRM） and its adjuvanticity when given in the combination with the experimental vaccine. |
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| Keywords: | Nonspecific/specific immunization E coli Gut immune cells Weaned pigs |
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