| 大鼠脊髓P物质对细胞免疫调节作用的研究 |
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| 引用本文： | 王伟,徐承焘.大鼠脊髓P物质对细胞免疫调节作用的研究[J].湛江医学院学报,1997,15(4):323-324,330. |
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| 作者姓名： | 王伟 徐承焘 |
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| 作者单位： | 广东医学院医用生化研究所!湛江，524023，中国医学科学院基础医学研究所，中国医学科学院基础医学研究所 |
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| 摘 要： | 目的：观察大鼠脊髓Ｐ物质对细胞免疫水平的影响，方法：两组新生大鼠分别皮下注射辣椒素（ＣＡＰ）和Ｐ物质抗血清，成年大鼠则于脊髓蛛网膜下腔注射，用丝裂原激活的大鼠脾细胞方法测定了淋巴细胞的白细胞介素－２（ＩＬ－２）水平。结果：大鼠皮下及脊髓蛛网膜下腔各分别注射ＣＡＰ，Ｐ物质抗血清后，ＩＬ－２的水平较对照组显著升高（Ｐ〈０．０１）。结论：新生大鼠（皮下）与成年大鼠（蛛网膜下腔）注射ＣＡＰ或Ｐ物质抗血清垃
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| 关 键 词： | 辣椒素 P物质抗血清 细胞免疫 脊髓 |
EFFECT OF SUBSTANCE P IN RAT SPINAL CORD ON THE REGULATION OF CELLULAR IMMUNITY |
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| Wang Wei,Xu Chengtao,Chen Juan.EFFECT OF SUBSTANCE P IN RAT SPINAL CORD ON THE REGULATION OF CELLULAR IMMUNITY[J].Journal of Guangdong Medical College,1997,15(4):323-324,330. |
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| Authors: | Wang Wei Xu Chengtao Chen Juan |
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| Institution: | Wang Wei1,Xu Chengtao2,Chen Juan2 |
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| Abstract: | Objective: To observe the effect of substance P in rat spinal cord on cellular immunity. Mcth-ods:Capsaicin(CAP) and substance P (SP) antiserum were subcutaneously injected into neonate rats,and intrathecally injected into adult rats. The levels of interleukin-2(IL-2)in supernatants obtained from the mitogen-stimulated rat spleen cells were measured. Results: The levels of IL-2 were significantly higher than those in control groups (P<0. 01),after CAP and SP antiserum were subcutaneously and in-trathecally injected respectively. Conclusion:The cellular immune function can be obviously enhanced by injecting CAP and SP antiserum subcutaneously into neonate rats and intrathecally into adult rats. |
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| Keywords: | capsaicin SP antiserum cellular immunity interleukin-2 |
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