1-(2-酰氧基-4,5-亚甲二氧基)苯基-2-甲基丙烯酮类化合物的合成及抑菌活性

以具有较高抑菌活性的卡枯醇衍生物1-(2-羟基-4,5-亚甲二氧基)苯基-2-甲基丙烯酮为原料,设计合成了14个未见文献报道的1-(2-酰氧基-4,5-亚甲二氧基)苯基-2-甲基丙烯酮类(2a～2n)化合物,其结构经电喷雾串联质谱(ESI-MS)和核磁共振氢谱确证。初步生物活性测试结果表明,在100 mg/L下,目标化合物对5种供试病原菌均具有较高的抑菌活性,其中, 2b和2d 对番茄灰霉病菌Botrytis cinerea和小麦赤霉病菌Fusarium graminearum的抑制率达100%。

Synthesis and antifungal activity of 1-(2-acyloxy-4,5-methylenedioxy) pheny1-2-methyl propylene ketones

Fourteen novel 1-(2-acyloxy-4,5-methylenedioxy)phenyl-2-methyl propylene ketones were designed and synthesized by reacting kakuol analogue 1-(2-hydroxy-4,5-methylenedioxy)phenyl-2-methyl propylene ketone which showing a higher antifungal activity with substituted acyl chloride.The structures of the compounds were confirmed by ESI-MS and ¹H NMR.Antifungal activity test showed that fourteen compounds exhibit strong inhibiting effect against all the tested strains at the concentration of 100 mg/L,and 2b,2d gave special effects on Botrytis cinerea and Fusarium graminearum with 100% inhibitation.