|
|||||
|
|
| 牛ANGPTL4基因结构和功能的生物信息学分析 | |
| 引用本文： | 马云,骆莹莹,李芬,王军芳,徐源,姚瑾,李荣荣,陈宏.牛ANGPTL4基因结构和功能的生物信息学分析[J].江西农业大学学报,2010,32(1). |
| 作者姓名： | 马云 骆莹莹 李芬 王军芳 徐源 姚瑾 李荣荣 陈宏 |
| 作者单位： | 1. 信阳师范学院,生命科学学院,河南,信阳,464000 2. 驻马店市平舆县第一高级中学,河南,驻马店,463300 3. 西北农林科技大学,动物科技学院,陕西,杨凌,712100 |
| 基金项目： | 河南省自然科学基金项目(092300410010);;信阳师范学院青年骨干教师资助计划(2006BAD04A16);;河南省高等学校青年骨干教师资助计划;;现代农业(肉牛)产业技术体系专项共同资助 |
| 摘 要： | 以牛ANGPTL4基因为研究对象,运用生物信息学方法对其编码蛋白的结构、理化性质、信号肽、跨膜结构、亚细胞定位、二级结构以及高级结构进行生物信息学分析,并推测与其他物种的生物进化关系。结果表明,牛ANGPTL4蛋白是一个疏水性不稳定蛋白,定位于细胞外。含有12个α-螺旋,8个β-折叠,30个转角,3个跨膜结构区域。通过分子进化树研究发现牛的ANGPTL4基因在人、小鼠、大鼠、猪、黑猩猩、狗、鸡等物种中,与猪的亲缘关系最近。 |
| 关 键 词： | 牛 血管生成素样蛋白-4（ANGPTL4） 序列分析 生物信息学 |
Bioinformatics Analysis of Bovine ANGPTL4 Gene Structure and Function |
|
| MA Yun,LUO Ying-ying,LI Fen,WANG Jun-fang,XU Yuan,YAO Jin,LI Rong-rong,CHEN Hong.Bioinformatics Analysis of Bovine ANGPTL4 Gene Structure and Function[J].Acta Agriculturae Universitis Jiangxiensis,2010,32(1). | |
| Authors: | MA Yun LUO Ying-ying LI Fen WANG Jun-fang XU Yuan YAO Jin LI Rong-rong CHEN Hong |
| Institution: | 1.College of Life Science/a>;Xinyang Normal University/a>;Xinyang 464000/a>;China/a>;2.The First Senior Middle School of Pingyu County/a>;Zhumadian 463300/a>;3.College of Animal Science and Technology/a>;North-west Agricultural & Forestry University/a>;Yangling 712100/a>;China |
| Abstract: | ANGPTL4 gene in cattle was investigated.By means of bioinformatics analysis its encoding protein was analyzed including its structure,physico-chemical property,signal peptide,transmembrane structure,subcellular localization,secondary structure and higher structure,and its evolution relationship with other species was inferred.The results indicated that ANGPTL4 protein of cattle was a kind of hydrophobicity labile protein,locating cellular exterior,which contained 12 α-helics,8 β-strands,30 turns and 3 transmembrane domains. It might be concluded that ANGPTL4 gene of cattle has closeet affinity with that of pig,compared with that of human,mus,rat,pan,dog and fowl based on the analysis of molecular evolution. |
| Keywords: | cattle angiopoietin-like 4(ANGPTL4) sequence analysis bioinformatics |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |