鸢尾素-前体基因:分子结构、表达调控和生物学功能及其与骨骼肌纤维类型转化

鸢尾素(irisin)是新近发现的可分泌型肌源细胞因子,来源于Ⅲ型纤连蛋白组件包含蛋白5水解形成的多肽片段。目前证明鸢尾素及其前体基因在糖脂代谢疾病发生与运动治疗中发挥作用,可能与骨骼肌纤维类型转化存在关联。本文通过总结鸢尾素及其前体基因分子结构特点、表达调控和生物学功能最新研究进展,结合骨骼肌纤维类型转化机制,探讨分析鸢尾素-前体基因途径与骨骼肌纤维类型转化潜在分子关联,以期为畜禽肉质改良提供新思路。

Irisin-Processor Gene：Molecul ar Structure,Expressive Regulation,Biological Functions and the Associations with Skeletal Muscle Fiber Types

Irisin, as a novel myogenic factor, is produced by shear from fibronectin typeⅢdomain containing protein 5 ( FNDC5) and then secretes into blood circulation system.Irisin and its processor gene FNDC5 ex-pression plays some roles on energy metabolism, obesity, diabetes and exercise therapy.This review summa-rized the recently research progresses about irisin and its processor gene FNDC5, majorly including their struc-ture characteristics and physiological functions.Their molecular associations with skeletal muscle fiber types were discussed, combining the extracellular and intracellular signaling pathways mediating the conversion a-mong different myofiber types.Our purpose was to provide some new ideas for improving pork quality through changing muscle fiber types.