柚皮素单硫酸酯钠盐对血栓形成和血小板聚集的影响

目的 观察柚皮素单硫酸酯钠盐(SNMS)对血栓形成和血小板聚集的影响.方法 将30只SD大鼠随机分为5组:SNMS1组、SNMS2组、血栓通组、肝素组和对照组,每组6只,麻醉大鼠,静脉注射药物后,用血栓生成仪观察大鼠颈动脉血栓形成情况；取兔血与药物孵育5min,凝血酶(500 U/L)作用1 min后,用全血血小板聚集...

Effect of sodium naringenin monosulfate on thrombosis and platelet aggregation

Objective To study the effect of sodium naringenin monosulfate （SNMS） on thrombosis and platelet aggregation. Methods Thirty SD rats were randomly divided into SNMS1 （5 mg/kg）, SNMS2 （10 mg/kg）, Xueshuantong （30 mg/kg）, heparin （1600 U/kg） and control groups, each of 6 ainmals. The thrombosis in the carotid artery was observed by thrombometer after intravenous injection of various drugs. Whole blood was detected by Chrono-log Platelet Aggregation System after treated with SNMS for 5 min and then thrombin （500 U/L） for 1 min. Results The block rates of carotid arteries were （10.2±17.9）%, （4.1±5.2）%, （7.8±9.0）%, （16.2±20.8）%, and （79.2±7.8）% in SNMS1, SNMS2, Xueshuantong, heparin and control groups, respectively. The block rates in SNMS groups were superior to those in control group （P〈0.01）, but similar to those in Xueshuantong and heparin groups （P〉0.05）. Platelet aggregation of whole blood was obviously inhibited by 160, 320 and 640 μmol/L SNMS （P〈0.01）, with the maximum agglutination being （8.50±3.87）, （11.50±2.38） and （9.50±3.11） Ω, respectively. Conclusion SNMS can suppress the thrombosis and platelet aggregation of whole blood.