变绿红菇子实体多糖的理化性质及其抗肿瘤活性

从变绿红菇子实体中提取出4种多糖,检测了它们的化学组成和分子量,并通过体内和体外实验,检测其抗肿瘤活性。结果表明,变绿红菇子实体的4种多糖为杂多塘,含有的单糖组分分别为木糖、葡萄糖、半乳糖、甘露糖以及果糖,其中葡萄糖为主要单糖组分。这4种多糖的重均分子量分别为3.1×107,6.5×105,5.1×105,8.0×105Da;多糖RVP2有较好的抗肿瘤活性,此发现为变绿红菇的深入开发利用提供了有价值的依据。

Physical,Chemical,and Antitumor Characteristics of Water-soluble Polysaccharides from the Fruiting Bodies of Russula Virescens

Four water-soluble polysaccharides were sequentially extracted from the fresh fruiting bodies of Russula virescens, and their chemical and physical characteristics were determined. The antitumor activities against Sarcoma 180 tumor cell (S-180) were then tested both in vitro and in vivo. The heteropolysaccharides consisted of xylose, mannese, glucose, galactose, and fructose. The weight average molecular weights (MWs) of polysaccharides RVP1, RVP2, RVP3, and RVP4 were determined to be 3.1×107,6.5×105,5.1×105, and 8.0×105Da, respectively. Except for RVP2, the other three polysaccharides were ineffective in suppressing S-180 growth. This find can the utilization of Russula virescens.