The genomic sequence of the bovine T cell receptor gamma TRG loci and localization of the TRGC5 cassette |
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| Authors: | Conrad Melanie L Mawer Melanie A Lefranc Marie-Paule McKinnell Linda Whitehead Joanne Davis Scott K Pettman Rachel Koop Ben F |
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| Affiliation: | University of Victoria, Centre for Biomedical Research, Victoria, British Columbia, Canada V8W 3N5. conradml@gmail.com |
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| Abstract: | The bovine and ovine TRG genes have previously been shown to be located in two loci, TRG1 and TRG2, in contrast to human and mouse TRG genes that are located in a single locus. The bovine TRG1 and TRG2 loci are located on chromosome 4 at 4q3.1 and 4q1.5-2.2, respectively. The complete genomic organization of the two bovine loci is described: each locus comprises three cassettes, each one includes one or several variable genes (TRGV) and one or several joining genes (TRGJ) preceding a constant (TRGC) gene. The location of the TRGC5 cassette is conclusively described in 5' of the TRG1 locus. Analysis of 17 TRGV belonging to 10 different subgroups, 8 TRGJ and 6 TRGC genes is conducted which comprises the most comprehensive list to date. |
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