| 促红细胞生成素在铅镉联合胁迫致雏鸡贫血中的作用 |
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| 引用本文： | 张陆,夏士亮,李金龙,徐世文.促红细胞生成素在铅镉联合胁迫致雏鸡贫血中的作用[J].畜牧兽医学报,2011,42(8). |
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| 作者姓名： | 张陆 夏士亮 李金龙 徐世文 |
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| 作者单位： | 东北农业大学动物医学院,哈尔滨,150030 |
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| 基金项目： | 国家自然科学基金项目(30901088); 黑龙江省教育厅科研基金项目(10551038); 东北农业大学大学生科技创新基金资助(2008103) |
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| 摘 要： | 为研究促红细胞生成素(EPO)在铅镉联合胁迫致雏鸡贫血中的作用,选用60只7日龄公雏鸡,平均分为对照组、铅组、镉组和铅镉组,每日经口灌服染毒,分别于第1、3、7天染毒后,检测雏鸡血液学指标和网织红细胞数量,并进行骨髓象的观察及红细胞膜ATP酶活性、红细胞渗透脆性和血清EPO含量的检测。结果表明铅镉单独染毒使雏鸡发生贫血,网织红细胞数量先增加后降低,骨髓象增生先活跃后受抑制,红细胞膜Na+-K+-ATPase、Ca2+-Mg2+-ATPase活性降低,红细胞渗透脆性增加,血清EPO含量先增加后降低,铅镉联合染毒也表现出上述变化,且较单独染毒组变化明显(P<0.05或P<0.01)。本研究证实铅、镉单独及联合染毒均可引起雏鸡发生贫血,贫血类型主要为再生障碍性和溶血性贫血,且铅与镉存在显著的协同效应;EPO参与了铅镉联合胁迫致雏鸡的贫血作用。
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| 关 键 词： | EPO 铅 镉 雏鸡 贫血 |
Roles of Erythropoietin in Chicken Anemia Induced by Lead and Cadmium |
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| ZHANG Lu,XIA Shi-liang,LI Jin-long,XU Shi-wen.Roles of Erythropoietin in Chicken Anemia Induced by Lead and Cadmium[J].Acta Veterinaria et Zootechnica Sinica,2011,42(8). |
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| Authors: | ZHANG Lu XIA Shi-liang LI Jin-long XU Shi-wen |
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| Institution: | ZHANG Lu,XIA Shi-liang,LI Jin-long,XU Shi-wen (Northeast Agricultural University,College of Veterinary Medicine,Harbin 150030,China) |
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| Abstract: | The purpose of this experiment was to study on the roles of erythropoietin(EPO) in chicken anemia induced by lead and cadmium.Sixty 7-day old chickens,which were administered daily per os,were divided into 4 groups: the control group,the lead group,the cadmium group and the lead-cadmium group.In the 1st,3rd,7th day,we tested the hematological parameters and the reticulocyte count,observed the image of bone marrow,meantime we also detected the erythrocyte membrane ATPase activity,the RBC osmotic fragility an... |
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| Keywords: | EPO lead cadmium chicken anemia |
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