|
|||||
|
|
Design, synthesis and anticoccidial activity of a series of 3-(2-(2-methoxyphenyl)-2-oxoethyl) quinazolinone derivatives |
|
| Authors: | Changwen Ye Junhui You Rong You Jun Li |
| Institution: | a Department of Chemical Engineering, Sichuan University, Chengdu 610064, PR China b National Hazardous Chemicals Quality Supervision and Inspection Center, Chengdu 610021, PR China c Department of Chemistry, Sichuan University, Chengdu 610064, PR China d Department of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, PR China |
| Abstract: | A series of 3-(2-(2-methoxyphenyl)-2-oxoethyl) quinazolinone derivatives were designed and synthesized as anticoccidial agents by modifying the quinazoline ring of febrifugine. All the compounds were biologically evaluated according to the ACI method, and four of them exhibited anticoccidial activity against Eimeria tenella in the chicken at a dose of 9 mg/kg. Compound 5e shows ACI value at 173.2 and is as potent as decoquinate. These data suggest that 5e possesses high anticoccidial activity and may serve as a lead compound for the development of anticoccidial drugs in the future. |
| Keywords: | Anticoccidial index method Anticoccidial activities Eimeria tenella 3-(2-(2-Methoxyphenyl)-2-oxoethyl) quinazolinone Synthesis |
| 本文献已被 ScienceDirect 等数据库收录！ | |