Limit of T cell tolerance to self proteins by peptide presentation |
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Authors: | H Schild O R?tzschke H Kalbacher H G Rammensee |
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Institution: | Max-Planck-Institut für Biologie, Abteilung Immungenetik, Tübingen, Federal Republic of Germany. |
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Abstract: | Cytotoxic T lymphocytes (CTLs) recognize foreign peptides bound to major histocompatibility complex (MHC) class I molecules. MHC molecules can also bind endogenous self peptides, to which T cells are tolerant. Normal mice contained CTLs specific for self peptides that were from proteins of ubiquitous or tissue-restricted expression. In vivo, these endogenous self peptides are not naturally presented in sufficient density by somatic cells expressing MHC class I molecules. They can, however, be presented if added exogenously. Thus, our data imply that CTLs are only tolerant of those endogenous self peptide sequences that are presented by MHC class I-positive cells in a physiological manner. |
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