猪冠状病毒性脑脊髓炎病理组织学及免疫病理学观察

对9例冠状病毒性脑脊髓炎仔猪病理组织学观察结果,本病是以脑脊髓软膜及实质的血管周围围以巨噬细胞和淋巴细胞;神经细胞变性、坏死;神经胶质细胞局灶性和弥散性增生为特征的非化脓性脑脊髓炎变化。病变在端脑、脑干、脊髓和半月状神经节都有分布,以小脑、延脑和桥脑的病变最重。免疫器官的免疫细胞反应是体液免疫和细胞免疫同时存在的混合免疫。

HISTOPATHOLOGICAL AND IMMUNOPATHOLOGICAL OBSERVATIONS ON PORCINE CORONAVIRAL ENCEPHALOMYELITIS

The histopathological and immunopathological observations were made in nine newborn Piglets (Duroc breed) naturally infected with coronavirus.Histopathologically,the disease is nonsuppurative encephalomyelitis characterized by Perivascular cuffing with macrophages and lymphoeytes,neuronal degeneration and necrosis,and focal or diffuse gliosis.The lesions may be found in the telencephalon,brain stem,spinal cord and gasserian ganglion whereas those of the cerebullum, medulla oblongata and Pons are most severe.The immune response of the immunoorgans is both cellular and humoral characteristically.