Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle |
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Authors: | Eduardo E Baroni Diego C Díaz Eduardo Picco Samanta Waxman Casilda Rodríguez Manuel I San Andrés Juan C Boggio |
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Institution: | Departamento de Farmacología, Facultad de Ciencias Veterinarias, Universidad Nacional del Litoral, Esperanza, Santa Fe, Argentina. |
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Abstract: | Sulphonamides are still being used widely, influenced by the low cost and the efficacy against many common bacterial infections,
since they present a broad spectrum of activity. The aim of this study was to determine the effect of age on the pharmacokinetic/pharmacodynamics
(PK/PD) integration of intravenous sulfamethazine (60 mg/kgbw) in cattle, and the possible therapeutic outcomes. Six healthy
female calves, at the age of one, three, seven and fifteen weeks were used. Normality analysis was assessed with the Shapiro-Wilk
test. Non-parametric tests for paired data were used. Plasma concentrations were quantified using HPLC/uv. Differences were
found between one-three-weeks-old calves and seven-fifteen-weeks-old calves, in pharmacokinetic parameters (clearance, area
under the concentration-time curve and elimination half-life) and in the PK/PD integration. The ratios obtained in PK/PD integration
(T>MIC, WAUC) confirm that it is necessary to apply twice the dose of sulfamethazine in ≥ 7 weeks-old cattle to reach a satisfactory
dosage regimen (MIC ≥ 32 μg/mL). |
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Keywords: | Age Cattle Pharmacokinetics PK/PD Sulfamethazine |
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