Functional characteristics of porcine peripheral T cells stimulated with IL-2 or IL-2 and PMA |
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| Authors: | In Su Cheon Sung-Moo Park Hye Jin Lee Ji Eun Hong Sang Yun Ji Byoung-Shik Shim Kwang Ho Kim Pil Seung Heo Yoo Yong Kim Hyun Jung Jung Hakhyun Ka Seung Hyun Han Manki Song Cheol-Heui Yun |
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| Affiliation: | 1. Department of Agricultural Biotechnology, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea;2. Laboratory Sciences Division, International Vaccine Institute, Seoul, Republic of Korea;3. Center for Food and Bioconvergence, Seoul National University, Seoul, Republic of Korea;4. National Institute of Animal Science, RDA, Republic of Korea;5. Department of Biological Science and Technology, Yonsei University, Wonju, Republic of Korea;6. Department of Oral Microbiology & Immunology, Dental Research Institute, BK21 Program, School of Dentistry, Seoul National University, Seoul, Republic of Korea |
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| Abstract: | In human or mouse, mature T cells express either CD4 or CD8, resulting in different functions in the periphery. Interestingly, porcine CD4 and CD8 double positive (DP) T cells are present in the blood, and their proportions change from youth to adulthood. However, the features of these cells in swine are poorly understood. We investigated the fate of porcine peripheral T cells based on their functional characteristics, including proliferation and the expression of CD4 and CD8 co-receptors. The results showed that all the populations changed their CD8 expression in a time-dependent manner and porcine T cells had different proliferative pattern from human T cells. The results further revealed that Th2 cytokines were increased later in porcine T cells compared to human T cells upon stimulation with IL-2 + PMA. Collectively, we found that the fate of porcine peripheral T cells is different from that of human T cells, and the changes occur in a time- and stimulation-dependent manner. |
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| Keywords: | Porcine Human T cells CD4+CD8+ double positive |
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