Widespread divergence between incipient Anopheles gambiae species revealed by whole genome sequences |
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| Authors: | Lawniczak M K N Emrich S J Holloway A K Regier A P Olson M White B Redmond S Fulton L Appelbaum E Godfrey J Farmer C Chinwalla A Yang S-P Minx P Nelson J Kyung K Walenz B P Garcia-Hernandez E Aguiar M Viswanathan L D Rogers Y-H Strausberg R L Saski C A Lawson D Collins F H Kafatos F C Christophides G K Clifton S W Kirkness E F Besansky N J |
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| Affiliation: | Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. |
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| Abstract: | The Afrotropical mosquito Anopheles gambiae sensu stricto, a major vector of malaria, is currently undergoing speciation into the M and S molecular forms. These forms have diverged in larval ecology and reproductive behavior through unknown genetic mechanisms, despite considerable levels of hybridization. Previous genome-wide scans using gene-based microarrays uncovered divergence between M and S that was largely confined to gene-poor pericentromeric regions, prompting a speciation-with-ongoing-gene-flow model that implicated only about 3% of the genome near centromeres in the speciation process. Here, based on the complete M and S genome sequences, we report widespread and heterogeneous genomic divergence inconsistent with appreciable levels of interform gene flow, suggesting a more advanced speciation process and greater challenges to identify genes critical to initiating that process. |
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