| Abstract: | A consequence of the recent study of the mechanism of gastric secretion has been the presumption, implicit (1) if not explicit (2), that the distinctive gastric transmucosal potential has a fundamental role in the formation of hydrochloric acid. The following report indicates that the isolated surviving elasmobranch gastric mucosa does secrete acid but, unlike that of other vertebrates, does so without developing a significant epithelial potential difference. The gastric transmembrane potential is neither necessary for hydrogen ion secretion nor is its generation a fundamental feature of the mechanism that leads to the formation of hydrochloric acid. |
