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Structures and Biological Activities of Secondary Metabolites from Trichoderma harzianum
Authors:Rui Guo  Gang Li  Zhao Zhang  Xiaoping Peng
Affiliation:1.Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao 266071, China;2.Department of Hand and Foot Surgery, Affiliated Hospital of Qingdao University, Qingdao 266003, China
Abstract:
The biocontrol fungus Trichoderma harzianum, from both marine and terrestrial environments, has attracted considerable attention. T. harzianum has a tremendous potential to produce a variety of bioactive secondary metabolites (SMs), which are an important source of new herbicides and antibiotics. This review prioritizes the SMs of T. harzianum from 1988 to June 2022, and their relevant biological activities. Marine-derived SMs, especially terpenoids, polyketides, and macrolides compounds, occupy a significant proportion of natural products from T. harzianum, deserving more of our attention.
Keywords:natural products   Trichoderma harzianum   marine sources   bioactivity   secondary metabolites
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