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| 伊曲康唑肌肉注射液的药代动力学研究 | |
| 引用本文： | 刘云,崔鹏博,常虹,陈曦,陈亮,李继昌,刘运枫. 伊曲康唑肌肉注射液的药代动力学研究[J]. 东北农业大学学报, 2010, 41(9) |
| 作者姓名： | 刘云 崔鹏博 常虹 陈曦 陈亮 李继昌 刘运枫 |
| 作者单位： | 东北农业大学动物医学学院,哈尔滨,150030;东北农业大学动物医学学院,哈尔滨,150030;东北农业大学动物医学学院,哈尔滨,150030;东北农业大学动物医学学院,哈尔滨,150030;东北农业大学动物医学学院,哈尔滨,150030;东北农业大学动物医学学院,哈尔滨,150030;东北农业大学动物医学学院,哈尔滨,150030 |
| 基金项目： | 黑龙江省教育厅重点项目，黑龙江省十一五重点项目 |
| 摘 要： | 以羟丙基-β-环糊精化合物做辅料对伊曲康唑分子进行包合,制成肌肉注射剂,以山羊为试验动物,用高效液相色谱-紫外检测器对伊曲康唑肌肉注射剂的药代动力学进行研究。结果表明,伊曲康唑肌肉注射后最高药物浓度(Cma)x为226.67ng·mL-1;达峰时间Tmax为3h;血药浓度-时间曲线面积(AUC)48h为0.33898×104ng·h-1·mL-1;血浆药物浓度维持时间357h。由此可知伊曲康唑包合剂肌肉注射后可以达到一定的有效血药浓度,可用于皮肤真菌病的治疗。 |
| 关 键 词： | 伊曲康唑 药代动力学 羟丙基-β-环糊精 |
Study on pharmacokinetics of itraconazole intramuscular injection |
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| LIU Yun,CUI Pengbo,CHANG Hong,CHEN Xi,CHEN Liang,LI Jichang,LIU Yunfeng. Study on pharmacokinetics of itraconazole intramuscular injection[J]. Journal of Northeast Agricultural University, 2010, 41(9) | |
| Authors: | LIU Yun CUI Pengbo CHANG Hong CHEN Xi CHEN Liang LI Jichang LIU Yunfeng |
| Abstract: | Hydroxypropyl-β-cyclodextrin compound to itraconazole elements for inclusion in this experiment,which is made of intramuscular injection.Meanwhile,goats as experimental animals,the pharmacokinetics of itraconazole intramuscular injection had studied with high-performance liquid chromatography-ultraviolet detector.The result showed that Cmax is 226.67 ng·mL-1,Tmax for 3 h,and AUC is 0.33898×104 ng·h-1·mL-1 for 48 h.Several parameters could be achieved in the treatment of skin fungus drug concentration,however,they are not ideal.The itraconazole hydroxypropyl-β-cyclodextrin inclusion of intramuscular injection has a certain feasibility into clinical. |
| Keywords: | itraconazole pharmacokinetics hydroxypropyl-β-cyclodextrin |
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