食用菌多糖的结构修饰及其修饰后的抗肿瘤活性研究进展

食用菌多糖是一种重要的生物大分子物质,具有多种生物活性。多糖的生物活性与本身的结构有着直接联系,因此,对多糖结构进行修饰,选择合适的修饰方法成为研究多糖的一个重要方向。本文主要综述了食用菌多糖的修饰方法及其抗肿瘤活性,包括食用菌多糖的硫酸化修饰、羧甲基化修饰、磷酸化修饰、乙酰化修饰,食用菌多糖的其他化学修饰等等。最后指出需要进一步研究食用菌多糖其他结构修饰的方法（除硫酸化修饰）,已获得修饰的食用菌多糖结构与药理功效的关系,和食用菌多糖的其他生物活性。

Structure Modification of Edible Fungi Polysaccharides and Their Antitumor Activities: A Review

Edible fungus polysaccharide is a kind of important biomacromolecules with various bioactivities. Polysaccharide bioactivities have direct relationship with their structure. Thus, for modifying polysaccharide structure, the suitable modification way becomes an important direction for polysaccharide research. This study summarizes the modification ways of edible fungus polysaccharide and their antitumor activities, including sulfated modification, carboxymethylation modification, phosphorylation modification, acetylation modification and other chemical modifications of edible fungus polysaccharide. At last, the future research directions are pointed out, such as the other modification ways (except sulfated modification), the relationship between the modified polysaccharide structure and the pharmacological efficacy, and the other bioactivities of edible fungus polysaccharide.