New Azaphilones,Seco-Chaetomugilins A and D,Produced by a Marine-Fish-Derived Chaetomium globosum |
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| Authors: | Takeshi Yamada Yasuhide Muroga Reiko Tanaka |
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| Institution: | Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan; E-Mail: (R.T.) |
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| Abstract: | Seco-chaetomugilins A and D were isolated from a strain of Chaetomium globosum that was originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, along with the chemical transformation from known chaetomugilins A and D. Seco-chaetomugilin D exhibited growth inhibitory activity against cultured P388, HL-60, L1210, and KB cells. |
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| Keywords: | fungus marine-fish Chaetomium globosum cytotoxicity chaetomugilins azaphilones chemical transformation alkaline degradation |
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