Antitumor activity of compounds isolated from leaves of Eriobotrya japonica |
| |
Authors: | Ito Hideyuki Kobayashi Eri Li Shu-Hua Hatano Tsutomu Sugita Daigo Kubo Naoki Shimura Susumu Itoh Yoshio Tokuda Harukuni Nishino Hoyoku Yoshida Takashi |
| |
Institution: | Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700-8530, Japan. |
| |
Abstract: | In a search for possible antitumor agents from natural sources, megastigmane glycosides and polyphenolic constituents isolated from the leaves of Eriobotrya japonica (Rosaceae) were found to inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced activation of Epstein-Barr virus early antigen in Raji cells. Roseoside and procyanidin B-2 were among the active compounds found in an in vitro assay; these compounds were further assessed for antitumor activity in vivo in a two-stage carcinogenesis assay on mouse skin. Roseoside significantly delayed carcinogenesis induced by peroxynitrite (initiator) and TPA (promoter), and its potency was comparable to that of a green tea polyphenol, (-)-epigallocatechin 3-O-gallate, in the same assay. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|