A cytotoxic antibody produced by allo-skin transplantation in cats |
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| Authors: | Y Hara H Ejima S Aoki M Tagawa S Motoyoshi S Ikemoto |
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| Institution: | Department of Surgery, School of Veterinary Medicine, Nippon Veterinary and Zootechnical College, Tokyo, Japan. |
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| Abstract: | A high titer of cytotoxic antibody against donor lymphocytes, tentatively designated as anti-F1, was found in one cat who received 3 times of skin allograft from the same donor. The anti-F1 antibody titer was 1:16, and the antibody activity was mostly detected in the IgG fraction. A cross-absorption test using erythrocytes from F1-positive animals revealed that the F1(+) antigen recognized by anti-F1 antibody was expressed on erythrocytes as well as lymphocytes. The frequencies of F1(+) and F1(-) types in 81 healthy cats, involving all the cats used for allo-immunization in the present study, were 30.9 and 69.1%, respectively. Moreover, F1 antigen was considered to be a hereditary antigen from family studies. |
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