Topical allogeneic platelet-rich plasma treatment for a massive cutaneous lesion induced by disseminated intravascular coagulation in a toy breed dog |
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Authors: | Tae-ho Chung Dae-seung Baek Namjung Kim Jin-ho Park Chul Park |
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Institution: | .Department of Animal Resources Science, Joongbu University, Chungnam, 312-702 Republic of Korea ;.Department of Veterinary Internal Medicine, BK21 Plus, Chonbuk National University, Jeonbuk, 561-756 Republic of Korea ;.National Academy of Agriculutral Science, Gyeonggi, 441-707 Republic of Korea |
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Abstract: | A 2-year-old intact female miniature Pinscher weighing 1.7 kg with a body condition score of 2/5 was presented for acute vomiting, lethargy for 2 days, and large petechial skin lesions on the hip region including the tail. Acute pancreatitis was diagnosed by clinical signs, strong positive cPLI test, laboratory test and ultrasound appearance. While the clinical signs associated with acute pancreatitis had improved in 3–5 days, lesion of petechial appeared on the left hip region 7 days after the presentation, with a fast progression into a necrotic tissue along the left side hip. Allogenic platelet rich plasma (PRP) with Weibrich and Kleis method was administered to promote skin healing and regeneration. Gradual and complete improvement in the dog’s wound lesions was noted approximately 1 month after applying allogeneic topical PRP. In this case report, allogeneic PRP was applied to a large regional cutaneous defect caused by coagulopathy induced by acute pancreatitis. Topical application of PRP in this case was unique in that allogeneic PRP was used instead of autologous PRP for the first time in cutaneous soft-tissue wound management in the veterinary medical field. |
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Keywords: | Platelet-rich plasma Disseminated intravascular coagulation Cutaneous lesion Toy breed dog Topical treatment |
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