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Histocytological specificities of adrenal cortex in the New World Monkeys, Aotus lemurinus and Saimiri boliviensis
Authors:Toru TACHIBANA  Ken Takeshi KUSAKABE  Sayuri OSAKI  Takeshi KURAISHI  Shosaku HATTORI  Midori YOSHIZAWA  Chieko KAI  Yasuo KISO
Affiliation:1)Laboratory of Basic Veterinary Science, The United Graduate School of Veterinary Science, 1677–1 Yoshida, Yamaguchi 753–8515, Japan;2)Amami Laboratory of Injurious Animals, Institute of Medical Science, The University of Tokyo, 802 Teyasu, Setouchi-cho, Ohshima-gun, Kagoshima 894–1531, Japan;3)Graduate School of Agricultural Science, Utsunomiya University, 350 Mine-machi, Utsunomiya, Tochigi 321–8505, Japan
Abstract:The New World monkey Aotus spp. (night monkeys) are expectedfor use of valuable experimental animal with the close species of Saimirispp. (squirrel monkeys). Saimiri is known to show spontaneoushypercortisolemia, although few reports in Aotus. We compared basicstates of blood steroid hormones and histological structure of the adrenal glands in twomonkeys. Serum cortisol and ACTH levels were statistically lower in Aotusthan Saimiri. Conversely, Aotus adrenocortical areashowed significant enlargement, especially at the zona fasciculata. Electron microscopicobservation at Aotus fasciculata cells revealed notable accumulation oflarge lipid droplets and irregular shapes of the mitochondrial cristae. These resultssuggest potential differences in cellular activities for steroidogenesis betweenAotus and Saimiri and experimental usefulness inadrenocortical physiology and pathological models.
Keywords:adrenal cortex   Aotus   cortisol   Saimiri
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