Effect of oral administration of L-pipecolic acid on food intake in chicks and mice |
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| Authors: | Tomo TAKAGI Ryuichi ANDO Atsushi OHGUSHI Tomonori NAKANISHI Hazizul HUSSAIN-YUSUF Ryoji ONODERA Hiroyuki SATO D. Michael DENBOW Mitsuhiro FURUSE |
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| Affiliation: | Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Higashi-ku, Fukuoka-shi,;Faculty of Agriculture, Miyazaki University, Miyazaki-shi,;Ajinomoto, Kawasaki-ku, Kawasaki-shi, Japan, and;Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA |
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| Abstract: | It has been demonstrated that L-pipecolic acid (L-PA), a major metabolic intermediate of L-lysine (L-Lys) in the brain, is involved in the functioning of the γ-aminobutyric acid-ergic system. Previous study has shown that intracerebroventricular injection of L-PA suppressed feeding and induced sleep-like behavior in neonatal chicks. The present study examines whether the action of L-PA was induced by gavage in both chicks and mice. Oral administration of L-PA significantly inhibited food intake at 2 h after treatment in neonatal chicks, although no significant effect of L-Lys was detected. In mice, oral L-PA suppressed food intake compared to the control after 2 h of treatment. It was concluded that L-PA was effective for suppression of food intake after oral administration in both avian and mammalian species. |
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| Keywords: | chicks food intake L-pipecolic acid mice oral injection |
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