肝脏与胰腺发育的分子调控

肝脏和胰腺均由内胚层发育而来的消化器官,它们广泛地参与糖代谢、脂类代谢和蛋白质代谢.肝脏和胰腺的发育是一个动态连续的过程,并受到多种信号途径及转录因子的调控.基于上述特点和显著的医用价值,笔者对肝脏和胰腺发育过程中的分子作用机理作了系统地阐述,这将不仅有助于理解与肝脏和胰腺相关疾病的发病机理.同时也为有效地指导相关疾病的预防及治疗工作提供分子理论基础.

Molecular Control of Liver and Pancreas Development

Liver and pancreas,derived from endoderm,are both important digestive organs.In vertebrate,liver and pancreas extensively take part in metabolism of glycogen,lipids and protein.Their development is a coordinated sequence of processes,and controlled by multi-signal pathways and transcription factors.Based on the above-mentioned facts and obviously medical importance,the molecular mechanisms of their development were elucidated in the paper,it will be useful for better understanding of diseases which are rela...