Toward the synthesis and biological screening of a cyclotetrapeptide from marine bacteria |
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Authors: | Dahiya Rajiv Gautam Hemendra |
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Institution: | Department of Pharmaceutical Chemistry, NRI Institute of Pharmacy, Bhopal 462 021, Madhya Pradesh, India. drrajivdahiya@rediffmail.com |
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Abstract: | The first synthesis of a naturally occurring tetrapeptide cyclo-(isoleucyl-prolyl-leucyl-alanyl) has been achieved using a solution-phase technique via coupling of dipeptide segments Boc-L-Pro-L-Leu-OH and L-Ala-L-Ile-OMe. Deprotection of the linear tetrapeptide unit and its subsequent cyclization gave a cyclopeptide, identical in all aspects to the naturally occurring compound. Bioactivity results indicated the antifungal and antihelmintic potential of the synthesized peptide against pathogenic dermatophytes and earthworms. |
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Keywords: | natural product synthesis marine bacteria cyclic tetrapeptide biological activity Halisarca ectofibrosa Diginea sp |
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