A new norlignan from Taxodium ascendens |
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| Authors: | Yu Mei Zhang Ning Hua Tan Guang Zhi Zeng Abiodun Humphrey Adebayo Chang Jiu Ji |
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| Institution: | aState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China;bDepartment of Biological Sciences, College of Science and Technology, Covenant University, PMB 1023, Ota, Ogun State, Nigeria |
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| Abstract: | A new norlignan, (2R,3R,4S,5S)-2,4-bis(4-hydroxyphenyl)-3,5-dihydroxy-tetrahydropyran (1), together with 9 known compounds were isolated from the branches and leaves of Taxodium ascendens. Their structures were mainly determined on the basis of MS, IR, 1D and 2D NMR spectral evidences. Methanol extract showed inhibitory activity on carbonic anhydrase II with an IC50 value of 4.27 µg/ml, acetone extract and methanol extract inhibited activity of cathepsin B with IC50 values of 2.12 and 3.71 µg/ml, respectively. |
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| Keywords: | Taxodiaceae Taxodium ascendens Norlignan |
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