Further degradation product of hyperforin from Hypericum perforatum (St John's Wort) |
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Authors: | Vajs V Vugdelija S Trifunovi? S Karadzi? I Jurani? N Macura S Milosavljevi? S |
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Institution: | Institute of Chemistry, Technology and Metallurgy, Njegoseva 12, Serbia and Montenegro, Belgrade 11000, Yugoslavia. |
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Abstract: | Repeated examination of the aerial parts of Hypericum perforatum yielded a new degradation product of hyperforin (1) namely deoxyfurohyperforin A (2), together with the previously identified furohyperforin (3), furoadhyperforin (4), furohyperforin A (5a and 5b), pyrano7,28-b]hyperforin (6) and 3-methyl-4,6-di(3-methyl-2-butenyl)-2-(2-methyl-1-oxopropyl)-3-(4-methyl-3-pentenyl)-cyclohexanone (7). The antimicrobial activity of the compounds 3, 5a and 5b, 6 and 7 was tested against Staphylococcus aureus, Candida albicans, Bacillus subtilis and Escherichia coli. |
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