Synthesis and anti-mildew activity of 5-(2-aroyl)aryloxymethyl-2-phenyl-1 ,3,4-oxadiazoles against downy mildew of pearl millet |
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Authors: | Khanum Shaukath A Shashikanth Sheena Sudha Belgur S Deepak Saligrama A Shetty Huntrike S |
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Institution: | Department of Chemistry, Yuvaraja's College, University of Mysore, Mysore-570 005, India. |
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Abstract: | A manipulatively simple, rapid, high-yielding and environmentally benign method for the integration of a heterocyclic ring, 1,3,4-oxadiazole, at the benzophenone nucleus has been achieved through intramolecular cyclization of substituted aroylaryloxyacetohydrazides to substituted 5-(2-aroyl)aryloxymethyl-2-phenyl-1,3,4-oxadiazoles under solventless 'dry' conditions using montmorillonite K10 clay and microwave irradiation. A comparison is made of the microwave-accelerated reaction with conventional heating conditions. Certain of the derivatives tested showed significant anti-mildew activity against Sclerospora graminicola (Sacc) Schroeter, the downy mildew pathogen of pearl millet. |
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Keywords: | microwave synthesis benzophenone derivatives antimildew activity pearl millet |
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