Nebenwirkungen von Toxaphen auf Maüse

Side-effects of Toxaphene of Mice. Albino-mice (swiss) and wild-captured voles and mice were given a high dose of 50 mg toxaphene (M 5055) per kg body weight daily for a period of some weeks or months. Three weasels and one ermine were fed on 300 of these sublethally poisoned mice without showing any negative effect. The following parameters of mice unpoisoned and poisoned with a sublethal dose of toxaphen were examined: mortality, number of litters, resorption rate of embryoes, growth, haematological values, activity of enzymes, amino acids and proteins in serum and urine. In the group of poisoned mice a slight increase of neutrophile blood cells (Tab. 2), a higher level of enzyme activities (SP, GPT, GT; Tab. 3) in serum and a typical change in uric proteins were observed. (Abb. 1).In the field 6 liters of toxaphen (M5055) were sprayed over a forest plantination of 1,5 ha for mouse control. The following development of mice, especially of the Common Vole (Microtus agrestis) was investigated with the capture, mark and recapture (CMR) method. Toxaphene had an influence on the parasitic complex of the vole for a long time. The number of fleas, mites, ticks, blood protozoa, grahemella and haemobartonella of the voles was reduced for more than 6 months in the treated area. This may be one reason for the fast recovery, good growth and increasing number of the voles observed after control with the insecticide toxaphene.

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Die Arbeiten wurden durch Mittel der Gesellschaft für Strahlen- und Umweltforschung (GSF), München-Neuherberg, unterstützt