The protection given by pilus and whole cell vaccines of Bacteroides nodosus strain 198 against ovine foot-rot induced by strains of different serogroups |
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| Authors: | D J STEWART B L CLARK J E PETERSON D L EMERY E F SMITH† D A GRIFFITHS† I J O'DONNELL‡ |
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| Institution: | *CSIRO Division of Animal Health, Animal Health Research Laboratory, Private Bag No. 1, P.O. Parkville, Victoria 3052;?CSIRO Division of Mathematics and Statistics, P.O. Box 218, Lindfield, New South Wales 2070;?CSIRO Division of Protein Chemistry, 343 Royal Parade, Parkville, Victoria 3052 |
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| Abstract: | A highly purified pilus vaccine prepared from cells of Bacteroides nodosus strain 198 provided a high level of protection against homologous challenge and small, not statistically significant, levels of protection against challenge with 4 other strains each from different serogroups. In a second experiment, a partially purified pilus vaccine from strain 198 induced significant immunity to 1 of 4 heterologous strains which were different from those used in the first experiment. In a third experiment a strain 198 whole cell vaccine produced significant immunity against 3 of 6 heterologous strains used in the first 2 experiments. There was no obvious relationship between the colony type, degree of piliation and level of cross-protection obtained against a particular strain. The results provide further evidence that immunogens associated with, but distinct from, the pilus are involved in cross-protection and that cross-protective antigens are common to some, but not all, strains. |
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