| 桦木醇戊二酸酯的合成及溶解性能分析 |
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| 引用本文： | 吕坤,田水清,方桂珍.桦木醇戊二酸酯的合成及溶解性能分析[J].林产化学与工业,2009,29(1):87-90. |
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| 作者姓名： | 吕坤 田水清 方桂珍 |
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| 作者单位： | 东北林业大学,生物质材料科学与技术教育部重点实验室,黑龙江,哈尔滨,150040 |
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| 基金项目： | 黑龙江省重大项目，东北林业大学青年科研基金 |
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| 摘 要： | 为了增强桦木醇的亲水性,对桦木醇的C-3位、C-28位羟基进行修饰,在吡啶作溶剂、二甲基氨基吡啶(DMAP)作催化剂的条件下,与戊二酸酐反应合成桦木醇戊二酸酯.采用FT-IR、 1 H NMR 和MS对产物进行结构表征,并且选用平衡法测定了桦木醇和桦木醇戊二酸酯在丙酮、无水乙醇、水和磷酸盐缓冲溶液(PBS,pH值7.4,)等不同溶剂中的溶解度.结果表明,在丙酮和无水乙醇中,桦木醇戊二酸酯的溶解度是桦木醇的33.52和22.65倍;在水中,桦木醇戊二酸酯的溶解度为 0.002 1 g(100 mL 水);在PBS中,桦木醇戊二酸酯的溶解度约为 0.001 5 g(100 mL PBS),目标产物的亲水性有了显著的改善.
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| 关 键 词： | 桦木醇 桦木醇戊二酸酯 合成 溶解性能 |
Synthesis of 3,28-Di-O-glutaryl-betulin and Analysis of Its Solubility Properties |
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| L Kun,TIAN Shui-qing,FANG Gui-zhen.Synthesis of 3,28-Di-O-glutaryl-betulin and Analysis of Its Solubility Properties[J].Chemistry & Industry of Forest Products,2009,29(1):87-90. |
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| Authors: | L Kun TIAN Shui-qing FANG Gui-zhen |
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| Institution: | Key Laboratory of Bio-based Material Science and Technology;Northeast Forestry University;Ministry of Education;Harbin 150040;China |
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| Abstract: | To improve water solubility of betulin,two acyl groups were introduced at C-3 and C-28 hydroxy groups of betulin.3,28-di-O-glutaryl-betulin was synthesized with pyridine as solvent and DMAP as catalyst from betulin and glutaryl anhydride.Its structure was characterized by FT-IR,1H NMR and MS.Solubility data of betulin and 3,28-di-O-glutaryl-betulin in acetone,ethanol,water and phosphate-buffered saline(PBS,pH value 7.4) were determined by equilibrium method.The results showed that in acetone and ethanol,sol... |
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| Keywords: | betulin 3 28-di-O-glutaryl-betulin synthesis solubility property |
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