Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF |
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Authors: | Maeda Takahiro Merghoub Taha Hobbs Robin M Dong Lin Maeda Manami Zakrzewski Johannes van den Brink Marcel R M Zelent Arthur Shigematsu Hirokazu Akashi Koichi Teruya-Feldstein Julie Cattoretti Giorgio Pandolfi Pier Paolo |
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Institution: | Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. |
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Abstract: | Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. We demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop into B lineage cells by repressing T cell-instructive signals produced by the cell-fate signal protein, Notch. We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage. |
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