峨眉千里光对小鼠急性毒性及蓄积毒性研究

评价峨眉千里光毒性作用,采用机率单位法（Bliss法）和固定剂量蓄积系数法考察了峨眉千里光叶和全草水提物对小鼠经口急性毒性及蓄积毒性。急性毒性结果显示,不同剂量的峨眉千里光叶和全草水提物均能导致小鼠发生中毒和死亡,引起小鼠肺和肝脏损伤;叶水提物LD50为62.28 g/kg,95%可信限为52.68-73.65 g/kg;全草水提物LD50为81.65 g/kg,95%可信限为70.15-94.53 g/kg。蓄积毒性结果显示,峨眉千里光叶和全草的蓄积系数K〉5。结果表明,峨眉千里光叶和全草水提物对小鼠有急性毒性作用,叶的毒性比全草强,肺和肝脏为毒性靶器官;两种水提物均有轻度蓄积毒性。

Studies on the acute and accumulative toxicity of aqueous extract from Senecio faberii Hemsl leaves and whole herb in mice

To evaluate the toxicity of Senecio faberii Hemsl, the acute and the accumulative toxicity tests in mice were carried out by Bliss method and continuous exposure at a fixed dose method. The results of acute toxicity test showed that toxic reactions, deaths, damage of lung and liver m mice were observed in groups of different duse; LD50, of Senecio faberii Hemsl leaves to mice was 62.28 g/kg with 95% confidence interval of 52.68 g/kg-73.65/kg; LD50 of whole herbs was 81.65 gfkg with 95% confidence interval of 70.15 g/kg-94.53 g/kg. The results of accumulative toxicity test of leaves and whole herbs showed that the accumulative coefficient K were both above 5. The conclusions were followed： aqueous extract of Senecio faberii Hemsl leaves and whole herb could cause acute toxic effects to mice： the toxicity of leave was higher than that of whole herb; lung and liver were toxic target organs; both of the aqueous extracts were mild accumulation toxicity.