Pyrosequencing of the rabies virus glycoprotein gene to demonstrate absence of vaccine-associated rabies cases following oral vaccination |
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| Authors: | Paola De Benedictis Cristian De Battisti Sabrina Marciano Franco Mutinelli Ilaria Capua Giovanni Cattoli |
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| Institution: | 1. Department of Veterinary Clinical Sciences, University of Teramo, Viale Crispi 212, 64100 Teramo, Italy;2. Department of Animal Medicine, Production and Health, University of Padova, Viale dell’Università 16, 35020 Legnaro (PD), Italy |
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| Abstract: | Replication competent vaccines have been used successfully for the control of terrestrial rabies, mainly in wildlife; however, these vaccine strains occasionally may induce rabies. In this study, a pyrosequencing protocol for the rapid identification of vaccine-associated rabies viruses was applied to the 2008–2011 Italian epidemic. There was no evidence of vaccine-associated rabies cases following oral vaccination of foxes with the SAG2 and SADB19 vaccine strains. |
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