| 高效液相色谱-质谱法检测乳及乳制品中青霉素类残留及其代谢产物的研究进展 |
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| 引用本文： | 张立佳,胡雪,白艳梅,康恺,段国霞,刘丽君,李翠枝.高效液相色谱-质谱法检测乳及乳制品中青霉素类残留及其代谢产物的研究进展[J].乳业科学与技术,2014(6):26-30. |
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| 作者姓名： | 张立佳 胡雪 白艳梅 康恺 段国霞 刘丽君 李翠枝 |
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| 作者单位： | 内蒙古伊利实业集团股份有限公司,内蒙古呼和浩特010110 |
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| 基金项目： | “十二五”国家科技支撑计划项目（2012BAK17800） |
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| 摘 要： | 综述了近年来高效液相色谱-串联质谱、超高效液相色谱-串联质谱法、超高效液相色谱-高分辨飞行时间质谱法、基质辅助激光解吸电离-傅里叶变换离子回旋共振质谱,在乳及乳制品中青霉素类残留及其主要酶解代谢产物、体内代谢产物等方面检测中的应用。从样品的提取、净化、色谱分离方式和质谱检测方式四方面进行了分析。
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| 关 键 词： | 乳制品 高效液相色谱-串联质谱 超高效液相色谱-串联质谱法 超高效液相色谱-高分辨飞行时间质谱法 基质辅助激光解吸电离-傅里叶变换离子回旋共振质谱 青霉素 代谢产物 |
Recent ApplicAtions of High PerformAnce Liquid ChromAtogrAphy-MAss Spectrometry for the DeterminAtion of Penicillins And Their MetAbolites Residues in Milk And DAiry Products |
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| ZHANG Li-jia,HU Xue,BAI Yan-mei,KANG Kai,DUAN Guo-xia,LIU Li-jun,LI Cui-zhi.Recent ApplicAtions of High PerformAnce Liquid ChromAtogrAphy-MAss Spectrometry for the DeterminAtion of Penicillins And Their MetAbolites Residues in Milk And DAiry Products[J].JOURNAL OF DAIRY SCIENCE AND TECHNOLOGY,2014(6):26-30. |
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| Authors: | ZHANG Li-jia HU Xue BAI Yan-mei KANG Kai DUAN Guo-xia LIU Li-jun LI Cui-zhi |
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| Institution: | (Inner Mongolia Yili Industrial Group Co. Ltd., Hohhot 010110, China) |
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| Abstract: | In this paper we review recent applications of high performance liquid chromatography-tandem mass spectrometry （HPLC-MS/MS）, ultra performance liquid chromatography-tandem mass spectrometry （UPLC-MS/MS）, ultra high performance liquid chromatography coupled with high-resolution time-of-flight mass spectrometry （HRTOF-MS）, and matrix assisted laser desorption ionization-Fourier transform ion cyclotron resonance mass spectrometry （MALDI-FTMS） to determine penicillin residues in milk and dairy products and their major enzymatic metabolites in vivo. This review describes recent progress in the development of sample extraction, purification, chromatographic separation and mass spectrometry detection methods for the determination of penicillin residues in dairy products. |
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| Keywords: | dairy products HPLC-MS/MS UPLC-MS/MS HRTOF-MS MALDI-FTMS penicillin metabolites |
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